Pharmacology - ANTIHISTAMINES (MADE EASY)

One of my favorite oral metabolic tools right now: 5-Amino-1MQ. It’s a selective NNMT (nicotinamide N-methyltransferase) inhibitor, which matters because NNMT overactivity is associated with impaired metabolic efficiency, fat storage signaling, and reduced NAD⁺ availability. In plain English: it nudges metabolism back toward using energy instead of defending fat. Why it stands out: • Oral, predictable absorption • Non-stimulant (no CNS push, no adrenergic spike) • Does not directly manipulate ho

Histamine intolerance is not driven by histamine intake alone. It’s driven by impaired degradation. There are two primary histamine-clearing pathways: \t1.\tDAO (extracellular, gut-dependent) \t2.\tHNMT (intracellular, methylation-dependent) While DAO gets most of the attention, HNMT is responsible for clearing histamine inside tissues, including the brain, liver, and lungs. HNMT requires SAMe, which is generated through the one-carbon (methylation) cycle. This is where COMT (catechol-O-methyltr