Hereditary Diffuse Gastric Cancer and CDH1 Gene Mutations
How is the CDH1 gene mutation diagnosed? Through genetic counseling and testing, we can identify mutations in the CDH1 gene. This test requires a blood or sputum sample. Targeted genetic testing …
Is stomach cancer hereditary? - MD Anderson Cancer Center
Jul 30, 2025 · Hereditary diffuse gastric cancer is a condition caused by the inherited CDH1 gene mutation that increases the risk of stomach cancer. Paul Mansfield, M.D., explains how it develops, …
Hereditary Diffuse Gastric Cancer (HDGC) - Johns Hopkins Medicine
Stomach Cancer CDH1 Screening Patients from families with the HDGC gene, as well as patients diagnosed with diffuse stomach cancer before age 40, are referred for genetic counseling and testing …
CDH1 gene: MedlinePlus Genetics
The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. Learn about this gene and related health conditions.
6 Questions Answered about the CDH1 Gene Mutation & Stomach Cancer
Jul 22, 2021 · Inheriting a mutation in the CDH1 gene can raise risk of a rare stomach cancer called hereditary diffuse gastric cancer.
CDH1 Gene Mutations: Risk, Management and Treatment
Jul 27, 2025 · CDH1 Gene Mutation Learn about the cancer risks, screening, prevention and treatment options for people with inherited CDH1 mutations. Stay up to date by signing up for our community …
Advancing the Evaluation and Management of CDH1-Associated …
Apr 1, 2025 · Gastric cancer is a significant global health concern, with CDH1-associated gastric cancer representing a small but important subset of cases. Historically, individuals with CDH1 pathogenic …
CDH1 Gene Mutation: Cancer Risks and Medical Management
Jul 24, 2025 · Explore how a CDH1 gene mutation affects cell behavior and increases hereditary cancer risk. Learn about identification and proactive health management strategies.
Germline CDH1 Variants and Lifetime Cancer Risk - JAMA Network
Jun 14, 2024 · Key Points Question In individuals with CDH1 gene variants, what is the lifetime risk of gastric and breast cancer? Findings In this multicenter, retrospective cohort and modeling study that …
A Comprehensive Literature Review of the CDH1 Mutation and Its
May 30, 2025 · Hereditary diffuse gastric cancer (HDGC) is a significant genetic predisposition syndrome, primarily caused by germline mutations in the CDH1 gene, which encodes the E-cadherin …