In pro-B cells, VDJ recombination at the immunoglobulin heavy chain locus is impaired. B cell progenitor recombination implies the formation of DNA double strand breaks (DSBs) by the RAG recombinase, ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The diversity of antibodies underpins robust ...
Desperate times call for proactive measures. Nonprofits are navigating an immensely challenging economic and political context. Many find themselves thinking about the once-unthinkable: mergers, ...
In this report, Yu et al ascribe potential tumor suppressive functions to the non-core regions of RAG1/2 recombinases. Using a well-established BCR-ABL oncogene-driven system, the authors model the ...
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RNA-Based Homologous Recombination Deficiency Signature Detects Homologous Recombination Deficiency-RNA+ Patients With and Without Homologous Recombination Repair Gene Pathogenic Alterations in Men ...
The musical mind behind the "Cha Cha Slide" — the ubiquitous turn-of-the-millennium dance hit played at celebrations and in gyms across the world — has died. DJ Casper died Monday after a long battle ...
To appropriately defend against a wide array of pathogens, humans somatically generate highly diverse repertoires of B cell and T cell receptors (BCRs and TCRs) through a random process called V(D)J ...
AIRRSHIP simulates B cell receptor (BCR) sequences for use in benchmarking applications where BCR sequences of known origin are required. AIRRSHIP replicates the VDJ recombination process from ...
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