Embryonic germ layers are the fundamental organizing principle in animal development. They provide the structural basis from which tissues and organs arise. During early embryogenesis, cells divide to ...

Ischemic diseases have become a major threat to global health, with endothelial cell (EC) damage closely associated with their pathogenesis and progression. Cell therapies targeting endothelial repair ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During gastrulation, mesodermal cells derived ...

Objectives: Critical Limb Threatening Ischemia (CLTI) is a health care priority with a 50% increase in amputations from 2010 to 2018. Unlike other cell products that simply secrete pro-angiogenic ...

Summary: Previously, scientists believed that the enteric nervous system (ENS) development stopped before birth. However, recent findings overturn this by showing ENS development continues after birth ...

Extended pluripotent stem cells (EPS cells) have unlimited self-renewal ability and the potential to differentiate into mesodermal, ectodermal, and endodermal cells. Notably, in addition to developing ...

The authors examine the process of mesoderm invagination in the Drosphila embryo and found that while myosin contractility is critical to prevent tissue relaxation during the early phase of the ...

Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its biological functions. By studying progenitors of the ...

1 Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, México 2 Departamento de Anatomía y Biología ...

Methylation of cytosine bases in DNA is an epigenetic modification that influences gene expression. TET (ten-eleven translocation)-family dioxygenases catalyze conversion of 5-methylcytosine (5mC) to ...