Just ahead of the NFL schedule release, Baltimore made a major contract move. The front office worked out a new two-year, $30 million extension with star running back Derrick Henry.

Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

The Bills begin the 2025 season in Baltimore against the Ravens -- and here's everything else to know about Buffalo's schedule.