Josh Downs will be a busy primary target for Flacco with Pittman out. He caught six passes last week and might better that number in this game. Alec Pierce is a viable downfield threat, and Adonai Mitchell might get more chances to contribute in the passing game this week.

The Buffalo Bills (7-2) visit the Indianapolis Colts (4-5) on Sunday in Week 10. Kickoff at Lucas Oil Stadium is scheduled for 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Bills vs.

Buffalo currently sits at No. 2 in the AFC, but there's a lot of football left to play, starting with a Week 10 clash against the Indianapolis Colts. Despite existing in the same conference, the Bills and Colts have not seen each other since 2021 in a game dominated by Indianapolis.