Parkinson’s Disease (PD) is an incurable neurodegenerative disease that causes movement disorders. Neurons in PD aggregate α-synuclein and are depleted from the substantia nigra (SN), which is a ...

A new multiplex immunofluorescence workflow using standard laboratory equipment and open-source software enables detailed ...

Researchers have demonstrated the feasibility of a morphological-based approach to interpreting spatial transcriptomic (ST) data, helping to improve understanding of the lesions that occur in chronic ...

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD can progress to ...

Plant immunity research has undergone a transformative shift with the advent of spatial and single-cell technologies, ...

Breakthrough research details how distinct tissue niches and cell communication contribute to chronic active lesions in MS. Study: Cell type mapping reveals tissue niches and interactions in ...

The researchers have developed a novel deep learning framework that integrates high-resolution pathology images with spatial transcriptomics and proteomics to reveal the complex intra-tumor ...

A novel study has found that obesity is associated with a distinct molecular program driving the transition from early-stage, ...

Illumina's spatial transcriptomics offering is slated to provide analyses of millions of cells per experiment across a 50 mm by 15 mm imaging area. (Pixabay) Illumina is raising the curtain on its ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

A study in The American Journal of Pathology introduces a method to combine traditional histopathology with spatial transcriptomic data, paving the way for the future of molecular microscopy and ...