He explained that excess iron in the heart muscle can weaken its pumping ability, disturb electrical conduction, and increase ...

Hemochromatosis is a condition that causes an overload of iron in the blood. Many people do not show any symptoms, but some experience fatigue and joint pain. It can either be inherited or caused by ...

What it is: Hemochromatosis is a genetic or acquired condition causing excess iron storage, which can damage the heart, liver, pancreas, and other organs over time. Why it matters: Untreated iron ...

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia. Patients with ...

Why ferritin matters: Ferritin stores and releases iron, fueling red blood cell production and oxygen delivery throughout the body. Low vs. high signs: Low levels can cause fatigue, dizziness, and ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Thalassemia is an inherited blood disorder that affects the body’s ability to produce normal hemoglobin, the protein in red ...

Sometimes, people with mild thalassemia may be told to supplement with iron. Iron supplements are only appropriate for certain types of thalassemia, though, and can be dangerous for people with more ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.