Figure 1: Application of RNAplfold to separate functional from nonfunctional siRNAs. Because it was previously claimed that regions of low G/C content coincide with efficient siRNA silencing 14 and ...

SHANGHAI and SANTA BARBARA, Calif., /PRNewswire/ -- Rona Therapeutics, a global leader in next-generation RNAi medicines, ...

RNA interference using small interfering RNAs (siRNAs) has become a mainstay of functional gene characterization and has generated over a dozen FDA-approved therapeutics and drugs in late-stage ...

The known siRNA design elements increased potency and specificity in the central nervous system to demonstrate the best activity after combining with vinyl phosphonate and C16, with up to 90 to 75 ...

When performing RNAi experiments using siRNAduplexes, the first critical challenge is the design ofefficient siRNA. Recent studies concerning the importanceof mRNA accessibility in relation to the ...

This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway will be ...

RNAi: Five Tips to Better Silencing - Table 4: Selected Online siRNA-Design Tools ...

Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong ...

The distribution of glycans on a monoclonal antibody impacts its function and half-life. Earlier this month, Masue Marbiah, PhD, a postdoctoral researcher at Imperial College London who develops ...

Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, will announce interim data from the ...