Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid ...

Pfizer and Novo Nordisk are locked in a bidding war for biotech firm Metsera as the pharmaceutical giants seek to augment ...

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, ...

The approval of the GLP-1 receptor agonist semaglutide for weight regulation in January 2023 ushered in a new era of obesity therapy. In recent months, however, drug regulatory authorities have also ...

Surprising findings published in PNAS have implications for understanding and treating neurological and neuropsychiatric disorders.

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate ...

A once-daily oral quadruple receptor agonist induced up to 13.8% weight loss at 13 weeks among adults with overweight or ...

The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

When Christopher Klebanoff, MD, came to Memorial Sloan Kettering Cancer Center (MSK) from the National Cancer Institute in 2016, he was focused on a singular goal: bringing the promise of cellular ...