Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In ...

Activation-induced deaminase (AID) initiates hypermutation of Ig genes in activated B cells by converting C:G into U:G base pairs. G₁-phase variants of uracil base excision repair (BER) and mismatch ...

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of ...

The H3.3 histone variant and its chaperone HIRA are involved in active transcription, but their detailed roles in regulating somatic hypermutation (SHM) of immunoglobulin variable regions in human B ...

Nanopore sequencing offers comparable accuracy to short-read NGS for IGH clonotyping in CLL, with advantages in cost and laboratory footprint. The study confirms reliable somatic hypermutation status ...

The enzyme activation-induced cytidine deaminase (AID) is central to the diversification of antibodies in B cells. By converting cytosine to uracil within single-stranded DNA, AID initiates somatic ...

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell ...

Scientists decipher how the antibody response of our immune system reacts to a coronavirus infection and prepares for future infections. Although SARS-CoV-2 is no longer a stranger to the immune ...

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. New research helps bolster the argument for getting COVID-19 booster shots now, even though the ...

Antibody- and cell-mediated immunity is known to be key to overcoming the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that has caused the coronavirus disease 2019 (COVID-19 ...