Here we show that PIH1D1 binds directly to two CK2-phosphorylated sites within the MRE11 C terminus. We further demonstrate that depletion of PIH1D1 resulted in MRE11 destabilization and that ...
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA ...
DNA repair is critical for avoiding cancer and other diseases. A molecular machine called the MRN complex finds and signals double-strand breaks and initiates error-free repair by means of homologous ...
BERKELEY, CA – Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for ...
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