Normally the lining of the colon forms a series of steep hills and valleys. At the surface, where the hills peak, are functional colon cells that do the organ's work of absorption and secretion. Deep ...

A team of neuroscientists has reprogrammed the brain’s own support cells to devour Alzheimer’s plaques in living mice, using nothing more than a single protein delivered by a carefully aimed virus.

Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with more than one million new diagnoses annually. Unfortunately, many cases are detected at advanced stages due to the lack ...

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...

Hypospadias is a widespread congenital disorder, characterized by an abnormal placement of the urethral opening, impacting as many as 3.42% of male children worldwide. Beyond the physical consequences ...

Mose model shows that SOX9 gene influences the severity Alagille syndrome. Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and ...

Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, ...

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes associated with colorectal cancer are known, how they contribute to cancer ...

Researchers working with Alzheimer’s disease mouse models have shown that manipulating a single factor in brain cells called ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers in western countries. 1 It has an extremely poor prognosis and lacks early diagnostic and therapeutic modalities. 2 ...