The San Francisco 49ers were hoping their rookies would be ready to pick up the slack after injuries to so many veteran players. Those hopes were dashed in Houston.

It was a fitting end for the 49ers. Jones took a shot to the end zone, targeting Jauan Jennings on the final play before the two-minute warning. His throw was intercepted by Texans cornerback Kamari Lassiter, ending San Francisco's last gasp attempt at a miracle comeback.

Houston held Christian McCaffrey to 68 yards with a plan that started up front and also included the Texans' offense.

Live San Francisco 49ers injury updates from the team's Week 8 game against the Houston Texans at NRG Stadium.

NFL Week 9 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and New York Giants.

The Sunday afternoon 49ers vs. Texans game will kick off at 1 p.m. ET. (Out-of-market fans can catch the game on YouTube TV 's Sunday Ticket, or NFL+.) Here's everything you need to know about how to watch this Sunday's game between the 49ers and the Texans, and get the full Week 8 schedule for the rest of the league.

The Atlanta Falcons traveled to Santa Clara, California to take on the San Francisco 49ers on "Sunday Night Football." Here's what happened in Week 7.

The San Francisco 49ers have been winning games with the next man up mentality. They have been able to get by with the depth and the talent that they do have st

The Texans face the 49ers in a virtual must-win game for their playoff hopes. We'll have updates and anlysis throughout the day from NRG Stadium.

The following players have been activated from the team's practice squad (standard elevations): The San Francisco 49ers today announced they have promoted DL Robert Beal Jr. to the active roster from the team's practice squad.

The San Francisco 49ers are used to playing shorthanded, but this week they will also face a foe that is coming in without their best player on offense. Nico Co

Sunday was National Tight End Day, and George Kittle gave 49ers fans the only ray of hope they would have all game in Houston. Kittle’s game wasn’t especially great (like every other San Francisco pass-catcher) with four receptions for 43 yards, but we will focus on his lone touchdown that will earn him Sunday’s first star.