The Texans are without two of their top wide receivers, Nico Collins and Christian Kirk. Also out for Houston are offensive tackles Trent Brown (the cousin of 49ers rookie defensive tackle Alfred Collins) and Jarrett Kingston (2024 sixth-round pick by the 49ers), defensive end Darrell Taylor, and quarterback Graham Mertz.

The San Francisco 49ers are in the midst of a major injury crisis, entering Sunday’s game against the Tampa Bay Buccaneers with a depleted roster missing starters Brock Purdy, George Kittle, Brandon Aiyuk,

The San Francisco 49ers expect rookie wide receiver Jordan Watkins to make his long-awaited NFL debut on Sunday night against the Atlanta Falcons. The fourth-round draft pick had impressed during training camp before a high-ankle sprain sidelined him in the preseason. Just as...

It's hard to imagine a more remarkable start to a 49ers career than what kicker Eddy Pineiro has had in his first month with the red and gold. For the second time, Pineiro hit a game-winning field goal against a division rival, this time to help the injury ...

OT Trent Williams addresses Jauan Jennings injuries after Buccaneers loss, sending a blunt message playing through pain.

Bethune steps into the starting lineup Sunday night when the 49ers host the Atlanta Falcons (5:20 p.m., NBC) at Levi’s Stadium, and the challenge couldn’t be more daunting. All he has to do is replace a four-time first-team All-Pro who one day may have a bust in Canton and whose leadership skills may even exceed his athletic gifts.

Sunday Night Football heads to the West Coast in Week 7 when the Atlanta Falcons (3-2) visit the injury-riddled San Francisco 49ers (4-2). This is SNF’s first trip to Levi’s Stadium this season, which will host Super Bowl LX on NBC on February 8, 2026.

A new NFL trade report claims the San Francisco 49ers see one specific player as a perfect in-season replacement for

The San Francisco 49ers had lost another star to an injury, given up a fourth-quarter lead on a safety and were relying on a backup quarterback and a brand new kicker to maintain their perfect start to the season.

San Francisco 49ers linebacker Fred Warner joins Hall of Fame quarterback Peyton Manning and former NFL quarterback Eli Manning on the 'ManningCast of MNF with Peyton and Eli'. Hall of Fame quarterback Peyton Manning and former NFL quarterback Eli Manning ...

With their season slipping away, the Houston Texans dominated the San Francisco 49ers for a 26-15 victory on Sunday. The Texans had a time-of-possession advantage of 41:22 to 18:38, the second-largest margin in the NFL this season.