The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...
Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.
Post-translational modifications (PTMs) of tubulin, including acetylation, glutamylation and detyrosination, play a critical role in dictating the dynamic behaviour and specialised functions of ...
The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...
At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...
Researchers discovered a novel protein modification driven by IDH mutations that alters cancer metabolism. The build-up of ...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds the host cell surface receptor angiotensin-converting enzyme 2 (ACE2). It is a glycosylated protein and is a target ...
A Nature study identifies a previously unknown protein modification, O-2-hydroxyglutarylation, driven by the oncometabolite ...
In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as ...