Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...

A microscope born in post-war JapanThis time, I am introducing an old Olympus biological microscope, the UCE model ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

Quantitative phase imaging is a powerful, non-invasive and quantitative microscopy technique that allows multi-scale imaging of cellular systems, explain Mustafa Mir and Gabriel Popescu Imaging by ...