The major histocompatibility complex (MHC) contains the most diverse genes known in vertebrates. High levels of polymorphism are often attributed to pathogen-mediated selection for potential immune ...

MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...

T cells play essential effectors and regulatory roles in adaptive immune responses to tumors, viruses, bacteria, parasites, transplanted tissues, allergens and even to self antigens. T cells use the T ...

Compared with the MHC of typical mammals, the chicken MHC is smaller and simpler, with only two class I genes found in the B12 haplotype. We make five points to show that there is a singledominantly ...