IgA nephropathy (IgAN) is the most common primary glomerulonephritis and a major cause of end-stage kidney disease 1. The pathological hallmark of IgAN is the deposition of predominantly IgA1 immune ...

An international research team from Bielefeld University and the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has uncovered a previously unknown regulatory mechanism in human cells.

Axonal dystrophy is a swollen and tortuous neuronal process that contributes to synaptic alterations occurring in Alzheimer’s disease (AD). Previous study identified that brain-derived neurotrophic ...

Lysosomes are organelles that play essential roles in cellular digestion and waste management, and lysosomal dysfunction typically leads to serious diseases. In a recent study, scientists developed a ...

Lysosomes play an important role in cells and tissues, controlling not only the degradation of substances but also cell division and growth. A team led by Professor Volker Haucke and Dr. Michael Ebner ...

Ishikawa, Japan - The correct functioning of our cells rests upon the precise orchestration of many complex processes and organelles. Lysosomes—vital cell organelles—are enzyme-filled subunits found ...