Researchers discover a gut-brain-heart axis where the bacterial metabolite IAA regulates hypocretin neurons to control heart stiffness and blood pressure.

Herbivore-induced volatile organic compounds prime non-attacked plant tissues to respond more strongly to subsequent attacks. However, the key volatiles that trigger this primed state remain largely ...

Plants produce an astonishing variety of chemical substances. Most of these metabolites are involved in chemical communication and serve to defend against pests, protect against pathogens, and attract ...

Scientists have identified new anti-aging compounds produced by a little-studied blood bacterium. These indole metabolites were able to reduce inflammation, oxidative stress, and collagen-damaging ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, ...

A cost-effective copper-catalyzed reaction enables selective modification at the C5 position of the indole ring, a backbone for pharmaceutical compounds Indole, a molecule made up of a six-membered ...

You’ve undoubtedly smelled indole. Perfumers add it to flowery fragrances, but it’s also added to chocolates, coffees, and fruity-flavored sweets. That doesn’t sound bad—until you learn that ...

Scientists have cracked one of chemistry’s toughest challenges with indoles, using copper to unlock a spot once thought too stubborn to change. The discovery could pave the way for easier, cheaper ...

The proposed method is simple, mild, fast, and produces high yields, with the potential to inspire the development of new drugs and agrochemicals. Indolo[2,3-a]quinolizidine is a common structural ...