DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late ...

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan.

Consequently, RK-33, the DDX3-inhibitor with great promise as a cancer fighter, is now being seriously considered for a second therapeutic function: a broad-spectrum antiviral agent. "We know that ...

Ideaya Biosciences Inc. has announced FDA clearance of an IND for a GSK-sponsored phase I/II trial of GSK-101 (IDE-705), a small-molecule inhibitor of Polϴ helicase, in combination with GSK's PARP ...

Viruses have limited genetic material -- and few proteins -- so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins. Now researchers have shown how the ...

Johns Hopkins Medicine-led study suggests small molecule inhibitor RK-33 can block multiple variants of the SARS-CoV-2 virus from replicating Based on findings from a new study by a Johns Hopkins ...