Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...
E3 ligases are enzymes that act as molecular "broker" by binding specific target proteins and coordinating the transfer of ubiquitin from an E2 enzyme. As an E3 ligase recognizes only a restricted set ...
Transverse tubules (T-tubules) play significant role in muscle contraction. However, the underlying mechanism of their ...
13don MSN
Boosting the cell's own cleanup: New class of small molecules accelerate natural protein degradation
Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in ...
Exploring pediatric E3 ligases to enable targeted protein degradation therapies for childhood cancer
This article and associated images are based on a poster originally authored by Ashleigh Hill, Marie-Louise Francis, Viktoria Brachmaier, Egle Vaitone, Rachel Forfar and Sandra Kuemper and presented ...
Data shows iberdomide combination therapy delivers progression free survival and safety in relapsed and refractory multiple ...
AZoLifeSciences on MSN
Mapping the human E3 ligase landscape
Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.
Three years after launching from the lab of University of California, San Francisco chemist Jim Wells, the start-up EpiBiologics has raised $109 million in series B funding to propel its ...
A collaboration led by CeMM, AITHYRA both in Vienna, Austria and the Max Planck Institute of Molecular Physiology in Dortmund ...
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