Nearly 50 years after the discovery of the walking molecular motor dynein, researchers have finally solved the first X-ray crystal structure of its massive motor domain. The milestone will permit ...

Processivity, the ability of single molecules to move continuously along a track, is a fundamental requirement of cargo-transporting molecular motors. Here, we investigate how cytoplasmic dynein, a ...

Diverse cellular processes require many tiny force-generating motor proteins to work in a team. Paradoxically, nature often chooses the weak and inefficient dynein motor to generate large persistent ...

Diverse cellular processes require many tiny force-generating motor proteins to work in a team. Paradoxically, nature often chooses the weak and inefficient dynein motor to generate large persistent ...

Harvard – Molecular motors, built from proteins, are a kind of transport service that keep cells functioning. They traffic essential chemical packages between the heart of the cell, the nucleus, and ...

Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. New data on ...

Movement signals life, and nowhere is this truer than inside a living cell. The millions of proteins and molecules within each of our cells bend, travel and conform in a complex but orchestrated ...

Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...

image: This artist's conception -- which will be the cover art for the April 16 issue of the journal Cell-- shows three molecular motors that help move cells and things inside them. The details of how ...

New research has uncovered how a "wimpy" protein motor works with two other proteins to gain the strength necessary to move nerve cells and components inside them. The findings shed light on brain ...