Immunotherapy that blocks microglial Fcγ receptors prevents dopaminergic neuron loss in Parkinson’s disease, revealing a potential new strategy.

By analyzing tissue from patients with Parkinson's disease, and animal and cellular models of the disease, a research team from the Institut de Neurociències of the UAB has shown that the main immune ...

Brain tissue analysis shows reactive microglia in Parkinson’s disease overexpress Fc gamma receptors, which may lead to inappropriate elimination of functional dopaminergic neurons. These findings ...

By analyzing tissue from patients with Parkinson's disease, and animal and cellular models of the disease, a research team from the Institut de ...

GPR6, a G protein-coupled receptor, is primarily expressed in the medium spiny neurons of the striatum, specifically within the striatopallidal pathway. This pathway is heavily impacted by the loss of ...

Tan, S., Hermann, B., and Borrelli, E. 2003. "Dopaminergic Mouse Mutants: Investigating the Roles of the Different Dopamine Receptor Subtypes and the Dopamine Transporters." The International Review ...

A recent study published in The New England Journal of Medicine has demonstrated that lixisenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, may slow the progression of motor disability in ...