Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

A molecular illustration of the crowded interior and cell envelope of Escherichia coli. (David S. Goodsell, The Scripps ...

Genome stability during DNA replication depends on a coordinated network of enzymatic activities that ensure accurate duplication and mitigate threats arising from DNA lesions, replication impediments ...

Bacterial DNA replication is a highly coordinated process that ensures faithful genome duplication and cell division. Replication initiates at a single chromosomal origin (oriC) where multiple copies ...