The Cardinals' season has hit rock bottom after another painful divisional loss, this time a 41-22 dismantling from the 49ers.

Arizona Cardinals QB Jacoby Brissett was injured on a play in the third quarter after a hard hit by Jaguars linebacker Devin Lloyd near the sideline.

Arizona Cardinals safety Budda Baker has been fined by the NFL following Week 11 action. Here’s what led to the league’s decision

Last season, the St. Louis Cardinals experimented with the leadoff spot but, regardless of the hitter, the team could not find the best fit for the number one slot in the lineup. In 2025, Cardinals’ leadoff hitters combined for a .

In his two games as the Cardinals' top wide receiver, Michael Wilson has 25 catches for 303 yards, taking full advantage of his larger opportunity.

Trevor Lawrence was sacked three times today against the Cardinals. Arizona also had five QB hits against him, including a fumble recovery touchdown from Walter Nolen. Sure, the Jaguars had 134 yards on the ground - but the Cardinals didn’t allow them to get in the end zone once in the run game.

The NFL fined Cardinals safety Budda Baker $17,389 for his hit on Seahawks WR Jaxon Smith-Njigba, ruling it unnecessary roughness on a defenseless receiver.

The St. Louis Cardinals announced that the franchise is letting three different pitchers leave the roster for free agency.

The Arizona Cardinals face the Jacksonville Jaguars Sunday at State Farm Stadium. Having lost seven of their last eight games, they want to pick up a win in front of the home fans. They are underdogs. There are a number of players to watch in this game. Some coincide with last week's matchup against the San Francisco 49ers, ultimately a 41-22 loss.