Advertisement Article continues below this ad 1925 — The New York Giants lose their first ... Dan Marino, who took 176 games to reach the mark, was the fastest. 2010 — Minnesota’s Brett Favre becomes the first NFL player to throw 500 touchdown ...

2014 — Peyton Manning breaks Brett Favre’s NFL record of 508 career touchdown passes and he throws four TD passes in Denver’s 42-17 victory over the San Francisco 49ers. The record-breaker was an 8-yarder to Demaryius Thomas with 3:09 left in the first half. Manning reaches the milestone in his 246th regular-season game. Favre needed 302.