Soft-tissue injuries are often prevalent early in the NFL season because there is less contact during training camp and preseason playing time for key contributors is limited. The league lost a few stars in recent weeks and now teams are tasked with filling that lost production.

No Kittle means the 49ers will be down three All-Pros on offense. The club figured to rely heavily on him while McCaffrey and Samuel were out. Now it appears Eric Saubert and Jake Tonges are in line for tight end snaps if Kittle is unable to play in Week 3.

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco 49ers (1-1) Sunday afternoon at SoFi Stadium. The list of issues thus far for the Rams is probably as long as their injury report.

See who's in and who's out for the Week 3 matchup between the San Francisco 49ers and Los Angeles Rams on September 22, 2024.

Get live streaming info, TV channel, game time, and head-to-head stats for the San Francisco 49ers vs. Los Angeles Rams week 3 game on Sunday, September 22, 2024.

We didn’t perform well because we didn’t do the things we’re capable of.” After an encouraging performance in Week 1, the Rams (0-2) got something of a wake-up call in the 41-10 loss to the Cardinals.